To start playing Talisman: The Magical Quest 5th Edition, first set up the game board. Lay out the large board that shows the land of Talisman with its 3 enchanted regions. Then, give each player a character figure and its matching card to learn about their unique ability. Shuffle the 100 Adventure cards and place them near the board. Each player takes turns moving their character around the board, drawing Adventure cards, and facing various challenges like enemies or finding magical objects. The goal is to be the first to find the Talisman, reach the Crown of Command, and defeat the guardian dragon. Remember, it's a mix of strategy and luck. For safety, keep small parts away from children under 12. When not in use, store the game in a cool, dry place to keep the cards and figures in good condition. Make sure to handle the cards gently to avoid damage.